2-(2,4-Dichlorophenylamino)-4-trifluoromethylpyrimidine-5-carboxylic acid [(tetrahydropyran-4-yl)methyl]amide

Name	GW842166X
Synonyms	CS-631 GW 842166 GW842166X GW 842166X 2-(2,4-dichloroanilino)-N-(oxan-4-ylmethyl)-4-(trifluoromethyl)pyrimidine-5-carboxamide 2-(2,4-dichlorophenylamino)-N-((tetrahydro-2H-pyran-4-yl)methyl)-4-(trifluoromethyl)pyrimidine-5-carboxamide 2-(2,4-Dichlorophenylamino)-4-trifluoromethylpyrimidine-5-carboxylic acid [(tetrahydropyran-4-yl)methyl]amide
CAS	666260-75-9
EINECS	200-258-5

Molecular Formula	C18H17Cl2F3N4O2
Molar Mass	449.25
Storage Condition	-20℃
In vitro study	GW842166X had similar potency at the rat and human recombinant protein CB2 receptors, with EC 50 of 91 nM and 63nM, respectively. The EC 50 value for full Agonist Efficacy GW-842166X was 133 and the E max was 101% on the cyclase assay. Its EC 50 for the detection of incomplete agonist potency by FLIPR was 7.780nm and the E max was 84%.
In vivo study	The oral bioavailability of GW842166X in the rat model was 58%, and the Half-Life was 3 hours. Its high efficacy, oral ED 50 0.1mg/kg. The 0.3mg/kg dose reverses pain sensation in the FCAa model of inflammatory pain. GW842166X at an oral dose of 15mg/kg for 8 days significantly reduced the foot threshold in a CCI-induced neuropathic pain rat model.

Last Update：2024-01-02 23:10:35

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CAS: 666260-75-9
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Product Name: GW842166X Visit Supplier Webpage Request for quotation
CAS: 666260-75-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

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2-(2,4-Dichlorophenylamino)-4-trifluoromethylpyrimidine-5-carboxylic acid [(tetrahydropyran-4-yl)methyl]amide Request for Quotation